abstract：:Levels of the beta-subunit of nerve growth factor (beta-NGF) were determined in various tissues from senescence-accelerated mice (SAM-P/8) and compared with those from senescence-resistant control mice (SAM-R/1) at 4 months of age. (1) In SAM-P/8, the testis was 30% larger in terms of wet weight than that from SAM-R/1...

journal_title：Mechanisms of ageing and development

authors： Katoh-Semba R,Semba R,Kashiwamata S,Kato K

更新日期：1991-06-14 00:00:00

abstract：:Experimental studies have not shown that the 'common' clinical experience, which suggests that wound healing is impaired in an old organism, is valid for healthy old experimental animals. We have developed a model in the rat for ischemic wound healing by using an H-shaped double skin flap, where the test wound is the ...

journal_title：Mechanisms of ageing and development

authors： Quirinia A,Viidik A

更新日期：1991-05-01 00:00:00

abstract：:Ageing of WI-38 fibroblasts in culture was used as a model in order to investigate the evolution and the alteration of the key antioxidant enzyme glutathione peroxidase. The activity of glutathione peroxidase is influenced by the presence of selenium in the culture medium and we have also shown that the specific activ...

journal_title：Mechanisms of ageing and development

authors： Pigeolet E,Remacle J

更新日期：1991-04-01 00:00:00

abstract：:We have developed a cell model for loss of differentiated gene expression in cellular aging. Over long periods in culture, bovine adrenocortical cells lose expression of a specialized gene, steroid 17 alpha-hydroxylase. The decline in expression of 17 alpha-hydroxylase in mass cultures and clones of bovine adrenocorti...

journal_title：Mechanisms of ageing and development

authors： Hornsby PJ,Yang LQ

更新日期：1991-04-01 00:00:00

abstract：:DNA-repair capacity, by incorporation in vitro of [3H]thymidine into DNA of isolated neuronal cells and splenic lymphocytes of rat was studied as a function of age. The incubations were carried out both in the presence and absence of hydroxyurea (HU), a known inhibitor of replicative DNA synthesis. The results indicat...

journal_title：Mechanisms of ageing and development

authors： Subrahmanyam K,Rao KS

更新日期：1991-03-01 00:00:00

abstract：:Arteriosclerosis is believed by many to represent the aging process of arteries and to be responsible for the cause-specific deaths at any age in industrialized countries. However, the increasing rate of (A) associated with steadily increasing life expectancy invited studies of the average age at death (AAD) of condit...

journal_title：Mechanisms of ageing and development

authors： Kaunitz H

更新日期：1991-02-01 00:00:00

abstract：:We have studied effects of long-term, low-dose growth hormone therapy on the immune function and life expectancy of Balb/c mice. Sixty male Balb/c mice were aged up to the time when they started showing signs of senescence and causal death (deaths started when they became 17 months old). The aged mice were divided int...

journal_title：Mechanisms of ageing and development

authors： Khansari DN,Gustad T

更新日期：1991-01-01 00:00:00

abstract：:In the lung of Rana perezi no differences as a function of age have been found for any of the five major antioxidant enzymes, reduced (GSH), oxidized (GSSG) or glutathione ratio (GSSG/GSH), oxygen consumption (VO2) and for in vivo or in vitro stimulated tissue peroxidation. This frog shows a moderate rate of oxygen co...

journal_title：Mechanisms of ageing and development

authors： Perez-Campo R,López-Torres M,Paton D,Sequeros E,Barja de Quiroga G

更新日期：1990-12-01 00:00:00

abstract：:Active oxygen species have been considered to be responsible for the aging process and for the induction and initiation of neoplastic processes. The effect of hydrogen peroxide, an active oxygen species, was investigated in the chromosomes of three young women (20-21 years of age) and of three elderly women (73-79 yea...

journal_title：Mechanisms of ageing and development

authors： Smith Mde A,Bortolotto MH,Melaragno MI,Toniolo Neto J

更新日期：1990-11-01 00:00:00

abstract：:As the endothelium ages it may become more susceptible to damage by atherogenic plasma components such as toxic lipid oxidation products. Vitamin E (vit E) might prove to be anti-atherogenic by reducing oxidative injury. This study investigated the effects of age and chronic exposure to fatty acid hydroperoxides (OFA)...

journal_title：Mechanisms of ageing and development

authors： Boissonneault GA,Hennig B,Wang Y,Wood CL

更新日期：1990-10-01 00:00:00

abstract：:The dynamics of in vitro uptake of [14C]-ascorbic acid into intact lenses of young (50 days old) and old (730 days old) guinea pigs was evaluated in this study. Two-dimensional protein gel analysis of [35S]-methionine labeled proteins provided evidence that the isolated lenses were viable throughout the culture period...

journal_title：Mechanisms of ageing and development

authors： Fleming JE,Choi S,Bensch KG

更新日期：1990-08-01 00:00:00

abstract：:Metabolite concentrations in gastrocnemius and soleus muscles were compared in young-adult (4 months), mature (12 months) and senescent (24 months) rats after continuous (72 consecutive hours) exposure to normobaric hypoxia or normoxia with the intraperitoneal administration of the vasodilator naftidrofuryl or saline ...

journal_title：Mechanisms of ageing and development

authors： Pastoris O,Dossena M,Allorio F,Vercesi L

更新日期：1990-06-01 00:00:00

abstract：:The bone marrow content, proliferative potential and proliferative activity of precursor cells for stromal fibroblast colony forming cells (CFC-F) were investigated in young and old CBA mice. The relationship between CFC-F and the number of bone marrow nucleated cells and granulocytic-macrophagal precursors (GM-CFC) w...

journal_title：Mechanisms of ageing and development

authors： Sidorenko AV,Andrianova LF,Macsyuk TV,Butenko GM

更新日期：1990-05-30 00:00:00

abstract：:Oxidative energy metabolism in mouse liver mitochondria was examined during weaning using different substrates. During the post-natal development, from suckling to weanling stage, the respiration rates showed a temporary decrease. These altered levels recovered in the adults. Respiration rates with the three substrate...

journal_title：Mechanisms of ageing and development

authors： Subramanian M,Katyare SS

更新日期：1990-05-30 00:00:00

abstract：:Some observations on cellular senescence are discussed regarding the possibility that the postulated genes, which bring about the DNA synthesis block of senescent fibroblasts, might be similar to those designated as anti-oncogenes or tumour suppressor genes. The latter genes have been defined by tumorogenicity tests o...

journal_title：Mechanisms of ageing and development

authors： Ferluga J

更新日期：1990-04-30 00:00:00

abstract：:Both vascular relaxation and cAMP accumulation mediated by beta adrenergic agonists declines with increasing age. We have developed a method to measure the biologically relevant cAMP bound to the regulatory subunits of cAMP-dependent protein kinase in rat aorta. In homogenates of rat aorta, binding of [3H]cAMP was sat...

journal_title：Mechanisms of ageing and development

authors： Chin JH,Hoffman BB

更新日期：1990-04-09 00:00:00

abstract：:The influence of age on liver gene expression was investigated in two strains of H-2 congenic mice. In B10.RIII mice (H-2r), basal P1- and P3-450 RNA levels progressively decreased 65 and 95%, respectively, between 4 and 28 months of age (P less than or equal to 0.05). Polyaromatic hydrocarbon (PAH) induced P1- and P3...

journal_title：Mechanisms of ageing and development

authors： Mote PL,Grizzle JM,Walford RL,Spindler SR

更新日期：1990-03-31 00:00:00

abstract：:Age-related changes in the activities of superoxide dismutase, catalase, and glutathione peroxidase were determined in brain, heart, hepatocytes, intestinal mucosa, and kidney from male Fischer F344 rats. Superoxide dismutase activity decreased significantly with age in all five tissues studied. The activity of catala...

journal_title：Mechanisms of ageing and development

authors： Rao G,Xia E,Richardson A

更新日期：1990-03-31 00:00:00

abstract：:An age-related decline in blood-brain barrier transport of thyroid hormones may contribute to the central nervous system changes with aging. To test this hypothesis, the brain uptake index (BUI) of levo (L) and dextro (D) triiodothyronine (T3) was determined in male Fischer 344 rats at 6 months of age (young) and 26 m...

journal_title：Mechanisms of ageing and development

authors： Mooradian AD

更新日期：1990-03-15 00:00:00

abstract：:The effect of age on potassium (K+)-induced norepinephrine release in the heart was studied in 6- and 24-month-old male Fischer-344 rats. Isolated hearts were perfused with Krebs-Ringer solution according to Langendorff method. K+ was employed as 2 ml bolus at the concentrations, of 70, 90, 100 and 120 microM. Norepin...

journal_title：Mechanisms of ageing and development

authors： Tumer N,Ryan PJ,Roberts J

更新日期：1990-03-01 00:00:00

abstract：:Age-related changes in blood-brain barrier permeability to macromolecules were investigated during electrically induced seizures. Evans-blue was used as the barrier tracer. There was no change in the permeability of the blood brain barrier associated with aging in the rats. However, the extravasation of Evans-blue alb...

journal_title：Mechanisms of ageing and development

authors： Oztas B,Kaya M,Camurcu S

更新日期：1990-02-01 00:00:00

abstract：:The age changes of neural control over the function of the thyroid, adrenal cortex and testicles were examined in adult (6 months) and old (28 months) male rats. In old age, there was a weakening of adrenergic control of thyroidogenesis, alpha-adrenergic and M-cholinergic control of glucocorticoid function of the adre...

journal_title：Mechanisms of ageing and development

authors： Frolkis VV,Gorban EN,Moroz EV

更新日期：1990-01-01 00:00:00

abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

journal_title：Mechanisms of ageing and development

authors： Koistinaho J,Alho H,Hervonen A

更新日期：1990-01-01 00:00:00

abstract：:Chondrocytes derived from chick embryos can be successfully implanted in defects of adult chick articular cartilage surfaces. Such implants thrive in their implantation site and create a new articular surface. The chondrocytes mature and hypertrophy in the orthotopic site without invoking an immune response. Eventuall...

journal_title：Mechanisms of ageing and development

authors： Robinson D,Halperin N,Nevo Z

更新日期：1989-10-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) vesicles isolated from skeletal muscle of Sprague-Dawley rats ranging in age from 4 months to 28 months were studied and compared. A marked decline, with age, was observed in the amount of (total) SR proteins isolated per gram of muscle tissue used. This decline is in line with the known lo...

journal_title：Mechanisms of ageing and development

authors： Gafni A,Yuh KC

更新日期：1989-08-01 00:00:00

abstract：:The general objective of this study was to examine the relationship between oxygen free radicals and the aging process. The rate of superoxide anion radical (O2.-) generation was measured in liver sub-mitochondrial particles from mouse, rat, rabbit, pig and cow, and in flight muscle sub-mitochondrial particles from th...

journal_title：Mechanisms of ageing and development

authors： Sohal RS,Svensson I,Sohal BH,Brunk UT

更新日期：1989-08-01 00:00:00

abstract：:The combined grafting of young bone marrow and newborn thymus performed in old mice was effective in restoring the impaired immune functions, but the same treatment performed in middle-aged adult mice had no effect on the life span of C3H/MTV female mice. Sequential multiple newborn thymus graftings starting at young ...

journal_title：Mechanisms of ageing and development

authors： Hirokawa K,Utsuyama M

更新日期：1989-07-01 00:00:00

abstract：:We have previously reported that two or more different subpopulations of bone marrow stem cells exist in mice as determined by cycling status of day-8 and day-14 CFU-S in long term bromodeoxyuridine (BrdU) infusion studies. In the present report, comparisons between cycling of stem cell subpopulations in old and young...

journal_title：Mechanisms of ageing and development

authors： Pietrzyk ME,Wolf NS,Priestley GV

更新日期：1989-07-01 00:00:00

abstract：:The effects of long-term caloric restriction on the hepatic phase II drug metabolizing enzymes were investigated in the male Fischer 344 rat. Rats that had been restricted to 60% of their pair-fed control consumption from 14 weeks post-partum exhibited altered conjugating enzyme activities at 22 months. Caloric restri...

journal_title：Mechanisms of ageing and development

authors： Leakey JA,Cunny HC,Bazare J Jr,Webb PJ,Lipscomb JC,Slikker W Jr,Feuers RJ,Duffy PH,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:In the present study, a number of physiological and behavioral measures that are related to metabolism were continuously monitored in 19-month-old male Fischer 344 rats that were fed ad libitum or fed a caloric restricted diet. Caloric restricted rats ate fewer meals but consumed more food during each meal and spent m...

journal_title：Mechanisms of ageing and development

authors： Duffy PH,Feuers RJ,Leakey JA,Nakamura K,Turturro A,Hart RW

更新日期：1989-05-01 00:00:00

abstract：:The kinetics of accumulation and loss of zinc from the liver following subcutaneous administration of 10 mg of zinc per kg were examined in young adult (6 months old) and old (24 months old) male C57BL/6J mice. After zinc treatment, total liver zinc concentrations rose equally in both groups and returned to basal leve...

journal_title：Mechanisms of ageing and development

authors： Thomas DJ,Winchurch RA,Adler WH

更新日期：1989-03-01 00:00:00

abstract：:The serotonin content of platelets, serum and plasma from rats of various ages was examined. In male rats, platelet serotonin content, which was about 0.65 nmol/10(8) platelets at young age (6-7 months), increased slightly at middle age (12-14 months) but decreased markedly at old age (25-26 months). Significant diffe...

journal_title：Mechanisms of ageing and development

authors： Yonezawa Y,Kondo H,Nomaguchi TA

更新日期：1989-01-01 00:00:00

abstract：:The results of this study show that an isogeneic barrier to the successful adoptive immunotherapy of Mycobacterium tuberculosis infected mice is progressively lost as these animals age. This was shown in this study by the demonstration that increasing levels of transferred acquired specific resistance could be conferr...

journal_title：Mechanisms of ageing and development

authors： Orme IM

更新日期：1988-12-01 00:00:00

abstract：:Hormone responsiveness is mediated by signal transduction mechanisms involving second messengers, such as cAMP and Ca2+, which regulate reversible changes in the phosphorylation state of proteins. During senescence individuals frequently exhibit a diminished responsiveness to hormones. We examined changes in enzymes i...

journal_title：Mechanisms of ageing and development

authors： Blumenthal EJ,Malkinson AM

更新日期：1988-12-01 00:00:00

abstract：:We have examined the effects of aging on guinea pig biliary motility both in vitro and in vivo. The first experiment compared contractile tension of gallbladder strips from young adult (6-12 months old) and 3-year-old guinea pigs in vitro. Contraction of gallbladder strips from the young guinea pigs was twice as force...

journal_title：Mechanisms of ageing and development

authors： Poston GJ,Singh P,Maclellan DG,Yao CZ,Uchida T,Townsend CM Jr,Thompson JC

更新日期：1988-12-01 00:00:00

abstract：:Long-term cultures of human umbilical endothelial cells were examined for changes in cell growth, cell density, cell volume, occurrence of multinucleated cells, prostacyclin production and negative charge of the cell surface during in vitro cellular ageing. The changes observed were consistent with the previously desc...

journal_title：Mechanisms of ageing and development

authors： Hasegawa N,Yamamoto M,Imamura T,Mitsui Y,Yamamoto K

更新日期：1988-12-01 00:00:00

abstract：:Cultured epiphyseal-chondrocytes from embryonic chick may serve as a useful in vitro model to study aging processes in cartilage. The accelerated aging process in cultured chondrocytes is completed within a month and is manifested by typical changes in both cellular and extracellular compartments. Under common mainten...

journal_title：Mechanisms of ageing and development

authors： Nevo Z,Beit-Or A,Eilam Y

更新日期：1988-11-14 00:00:00

abstract：:It has been shown in several studies that 2-mercaptoethanol (2-ME) improves the life span and aspects of life performance of laboratory animals. To obtain further details on the beneficial effects of 2-ME, a long-term study has been performed on male CBA/Ca inbred mice treated with this antioxidant. Four month-old mic...

journal_title：Mechanisms of ageing and development

authors： Pénzes L,Noble RC,Beregi E,Imre S,Izsák J,Regius O

更新日期：1988-10-01 00:00:00

abstract：:The activity of RU 41740, a glycoprotein extract from Klebsiella pneumoniae has been investigated on some polymorphonuclear (PMN) functions. Chemotaxis, random migration and oxidative metabolism (assessed by chemiluminescence, O2 consumption and O2- generation) were studied in parallel. PMN were collected from adult a...

journal_title：Mechanisms of ageing and development

authors： el Abbouyi A,Roch-Arveiller M,Marchiani C,Dahan R,Congy F,Paul JL,Giroud JP,Raichvarg D

更新日期：1988-09-01 00:00:00

abstract：:Changes in activity of some hepatic enzymes related to UDP-glucuronic acid conjugation (UDP-glucose dehydrogenase and UDP-glucuronyl transferase) and glutathione-related enzymes (glutathione reductase and glutathione peroxidase) were investigated in male and female Wistar rats as a function of age. UDP-glucose dehydro...

journal_title：Mechanisms of ageing and development

authors： Santa Maria C,Machado A

更新日期：1988-08-01 00:00:00